Endocrine Abstracts

Orexins are hypothalamic peptides known to stimulate food intake. Recently, orexins have been shown to activate the HPA axis at a central level1. We have previously shown that during late pregnancy the responsiveness of the HPA axis to a range of stressors is attenuated and suggested that the corticotropin releasing hormone (CRH) neurones or pathways impinging on them are less responsive2. If the CRH neurones themselves are less responsive, they should al...

Introduction: Studies of traumatic brain injury from all causes have found evidence of chronic hypopituitarism, defined by deficient production of one or more pituitary hormones at least 1 year after injury, in 25–50% of cases. Most studies found the occurrence of posttraumatic hypopituitarism (PTHP) to be unrelated to injury severity. Growth hormone deficiency (GHD) and hypogonadism were reported most frequently. Hypopituitarism, and in particular adult GHD, is associate...

INTRODUCTION: We have been interested to investigate the biological activity of mutant molecules of growth hormone. Purification of growth hormone requires multiple steps. We have investigated a method to purify growth hormone which would be applicable to most protein hormones that bind to cell surface receptors.AIM: To test whether his-tagged extracellular domain growth hormone receptor could be used to purify recombinant growth hormone.<p class="ab...